Article
Risk of syncope in family members who are genotype-negative for a family-associated long-QT syndrome mutation.
Circulation. Cardiovascular genetics - 1 Oct 2011
Barsheshet Alon, Moss Arthur J, McNitt Scott, Polonsky Slava, Lopes Coeli M, Zareba Wojciech, Robinson Jennifer L, Ackerman Michael J, Benhorin Jesaia, Kaufman Elizabeth S, Towbin Jeffrey A, Vincent G Michael, Qi Ming, Goldenberg Ilan
Abstract excerpt
BACKGROUND: Current clinical diagnosis of long-QT syndrome (LQTS) includes genetic testing of family members of mutation-positive patients. The present study was designed to assess the clinical course of individuals who are found negative for the LQTS-causing mutation in their families. METHODS AND RESULTS: Multivariate Cox proportional hazards model was used to assess the risk for cardiac events (comprising...
Topics
- Adolescent
- Adult
- Amino Acid Substitution
- Child
- Child, Preschool
- Death, Sudden, Cardiac
- ERG1 Potassium Channel
- Ether-A-Go-Go Potassium Channels
- Family