Article
Prevalence of hereditary haemochromatosis in premature atherosclerotic vascular disease.
British journal of haematology - 1 Sept 1998
Franco R F, Zago M A, Trip M D, ten Cate H, van den Ende A, Prins M H, Kastelein J J, Reitsma P H
Abstract excerpt
It has been proposed that iron accumulation may contribute to atherogenesis by increasing free radical formation and oxidative stress. Epidemiological studies in which the association of iron status with atherosclerosis was assessed raised conflicting results. To test whether genetic haemochromatosis is associated with increased atherosclerosis, we determined the prevalence of two mutations in the HFE gene...
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