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Article

HFE gene mutations in coronary atherothrombotic disease.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Mar 2000

Calado R T, Franco R F, Pazin-Filho A, Simões M V, Marin-Neto J A, Zago M A

Abstract excerpt

Although iron can catalyze the production of free radicals involved in LDL lipid peroxidation, the contribution of iron overload to atherosclerosis remains controversial. The description of two mutations in the HFE gene (Cys282Tyr and His63Asp) related to hereditary hemochromatosis provides an opportunity to address the question of the association between iron overload and atherosclerosis. We investigated the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10719381
DOI: 10.1590/s0100-879x2000000300007

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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HFE gene mutations in coronary atherothrombotic disease.PMID 10719381Read ↗

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HFE mutations in heart disease.Semantic proximity Read ↗

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A prospective study of coronary heart disease and the hemochromatosis gene (HFE) C282Y mutation: the Atherosclerosis Risk in Communities (ARIC) study.Semantic proximity Read ↗

Mutations in the hemochromatosis gene (HFE) and stroke.Semantic proximity Read ↗

Association studies between haemochromatosis gene mutations and the risk of cardiovascular diseases.Semantic proximity Read ↗

Mutations in the HFE gene and cardiovascular disease risk: an individual patient data meta-analysis of 53 880 subjects.Semantic proximity Read ↗

Hemochromatosis (HFE) genotype and atherosclerosis: Increased susceptibility to iron-induced vascular damage in C282Y carriers?Semantic proximity Read ↗

Haemochromatosis gene mutations and risk of coronary heart disease: a west of Scotland coronary prevention study (WOSCOPS) substudy.Semantic proximity Read ↗

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