Article
Hemochromatosis (HFE) genotype and atherosclerosis: Increased susceptibility to iron-induced vascular damage in C282Y carriers?
Atherosclerosis - 1 Aug 2010
Engberink Mariëlle F, Povel Cecile M, Durga Jane, Swinkels Dorine W, de Kort Wim L A M, Schouten Evert G, Verhoef Petra, Geleijnse Johanna M
Abstract excerpt
BACKGROUND: The C282Y mutation of the hemochromatosis (HFE)-gene increases body iron status. Among Caucasians, the carrier frequency of this mutation is 8-9%. C282Y carriers may be more susceptible to iron-induced atherosclerosis due to higher iron levels. It has also been postulated that the C282Y mutation could alter aspects of iron metabolism. We examined the relationship between the C282Y mutation, iron...
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