Mitochondrial Function, Morphology, and Axonal Transport in Amyotrophic Lateral Sclerosis

Abstract excerpt

Perturbation of organellar axonal transport is increasingly recognized as an important contributor in a number of neurodegenerative diseases. Although the specificity of this impairment remains to be elucidated, growing evidence suggests that in certain disease conditions, mitochondria are affected primarily by transport defects. Many hypotheses have been formulated to explain the pathogenic mechanisms involved...

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