Article
Adult and neonatal anti‐Gal response in knock‐out mice for α1,3galactosyltransferase
1 Aug 1998
Abstract excerpt
The knockout mouse to alpha1,3galactosyltransferase (alpha1,3GT KO) lacks the ability to synthesize alpha-gal epitopes (Galalpha1,3Galbeta1,4GlcNAc-R) and is capable of producing low amounts of the natural anti-Gal antibody. The present study indicates that repeated immunization of these mice with rabbit red blood cell (RRBC) membranes results in production of anti-Gal in titers and specificity similar to those...
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