Molecular cloning of a mutated HOXB7 cDNA encoding a truncated transactivating homeodomain-containing protein.

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Article

Molecular cloning of a mutated HOXB7 cDNA encoding a truncated transactivating homeodomain-containing protein.

Journal of cellular biochemistry - 1 Oct 1998

Chariot A, Senterre-Lesenfants S, Sobel M E, Castronovo V

Abstract excerpt

Homeodomain-containing proteins regulate, as transcription factors, the coordinated expression of genes involved in development, differentiation, and malignant transformation. We report here the molecular cloning of a mutated HOXB7 transcript encoding a truncated homeodomain-containing protein in MCF7 cells. This is a new example of mutation affecting the coding region of a HOX gene. In addition, we detected two...

Topics

Breast Neoplasms
Cloning, Molecular
Codon, Terminator
DNA, Complementary
Homeodomain Proteins
Humans
Mutation
Transcription, Genetic
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 9736453

Genes

HOXB7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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