An adenovirus type 5 mutant with the preterminal protein gene deleted efficiently provides helper functions for the production of recombinant adeno-associated virus.

doi:10.1128/JVI.72.10.8371-8373.1998

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Article

An adenovirus type 5 mutant with the preterminal protein gene deleted efficiently provides helper functions for the production of recombinant adeno-associated virus.

Journal of virology - 1 Oct 1998

Maxwell I H, Maxwell F, Schaack J

Abstract excerpt

Production of recombinant adeno-associated virus (rAAV) requires helper functions that have routinely been provided by infection of the producer cells with adenovirus. Complete removal and/or inactivation of progeny adenovirus, present in such rAAV preparations, presents significant difficulty. H...

Topics

Adenoviridae
Cell Line
Defective Viruses
Dependovirus
Gene Deletion
Humans
Mutation
Phosphoproteins
Protein Precursors
Viral Proteins

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