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Article

Interleukin (IL) 4 and IL-13 act on human lung fibroblasts. Implication in asthma.

The Journal of clinical investigation - 15 May 1998

Doucet C, Brouty-Boyé D, Pottin-Clémenceau C, Canonica G W, Jasmin C, Azzarone B

Abstract excerpt

Airway hyperresponsiveness leading to subepithelial fibrosis is mediated by inflammatory cells activated by T helper (Th) 2-derived cytokines such as IL-4 and IL-5. By analyzing the phenotype and response of human lung fibroblasts derived from either fetal (ICIG7) or adult (CCL202) tissue as well as from a Th2-type stromal reaction (FPA) to IL-4 and IL-13, we provide evidence that human lung fibroblasts may...

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Identifiers

PMID: 9593769
DOI: 10.1172/JCI741
PMCID: PMC508801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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