Article
A conservative amino acid mutation in the chromosome-encoded dihydrofolate reductase confers trimethoprim resistance in Streptococcus pneumoniae.
The Journal of infectious diseases - 1 Sept 1998
Pikis A, Donkersloot J A, Rodriguez W J, Keith J M
Abstract excerpt
Multidrug-resistant Streptococcus pneumoniae strains have emerged over the past decade at an alarming rate. The molecular mechanism of trimethoprim resistance was investigated in 5 pneumococcal strains isolated in the Washington, DC, area from patients with invasive infections. Cloning and sequen...
Topics
- Amino Acid Sequence
- Anti-Bacterial Agents
- Base Sequence
- Chromosomes, Bacterial
- Conserved Sequence
- DNA, Bacterial
- Drug Resistance, Microbial
- Humans
- Molecular Sequence Data
- Mutation
- Sequence Homology, Amino Acid
- Streptococcus pneumoniae
- Tetrahydrofolate Dehydrogenase
- Trimethoprim