Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel expansions of the gene encoding dihydropteroate synthase in trimethoprim-sulfamethoxazole-resistant Streptococcus pneumoniae.

Antimicrobial agents and chemotherapy - 1 Sept 1999

Padayachee T, Klugman K P

Abstract excerpt

A study of eight sulfonamide-resistant clinical isolates of Streptococcus pneumoniae revealed chromosomal mutations within the gene encoding dihydropteroate synthase that play a role in conferring resistance to sulfamethoxazole. The presence of the suld mutation, found previously only in a laboratory mutant, was shown to occur in three of the wild-type clinical isolates. The duplication of Ser(61), the other...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Bacterial Agents
Share to Dihydropteroate Synthase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Microbial

Share to Microbial Sensitivity Tests

Share to Streptococcus pneumoniae

Share to Sulfonamides

Share to Transformation, Genetic

Share to Trimethoprim, Sulfamethoxazole Drug Combination

Source

Open in PubMed Open full text

Identifiers

PMID: 10471569
DOI: 10.1128/AAC.43.9.2225
PMCID: PMC89451

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel expansions of the gene encoding dihydropteroate synthase in trimethoprim-sulfamethoxazole-resistant Streptococcus pneumoniae.PMID 10471569Read ↗

Mechanism of sulfonamide resistance in clinical isolates of Streptococcus pneumoniae.Semantic proximity Read ↗

Update on Dihydropteroate Synthase (DHPS) Mutations in Pneumocystis jiroveciiSemantic proximity Read ↗

Amino Acid Repetitions in the Dihydropteroate Synthase of Streptococcus pneumoniae Lead to Sulfonamide Resistance with Limited Effects on Substrate K mSemantic proximity Read ↗

Mutations in the dihydrofolate reductase gene of trimethoprim-resistant isolates of Streptococcus pneumoniaeSemantic proximity Read ↗

The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations in Staphylococcus aureus Dihydropteroate SynthaseSemantic proximity Read ↗

Analysis of random mutations in Salmonella Gallinarum dihydropteroate synthase conferring sulfonamide resistance.Semantic proximity Read ↗

A conservative amino acid mutation in the chromosome-encoded dihydrofolate reductase confers trimethoprim resistance in Streptococcus pneumoniae.Semantic proximity Read ↗

Dihydropteroate synthase gene mutations in Pneumocystis and sulfa resistance.Semantic proximity Read ↗

Dihydropteroate synthase polymorphisms in Pneumocystis carinii.Semantic proximity Read ↗

A Naturally Occurring Gene Amplification Leading to Sulfonamide and Trimethoprim Resistance in Streptococcus agalactiaeSemantic proximity Read ↗

Sulfonamide resistance in clinical isolates of Campylobacter jejuni: mutational changes in the chromosomal dihydropteroate synthase.Semantic proximity Read ↗

Mutations and horizontal transmission have contributed to sulfonamide resistance in Streptococcus pyogenes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.