Article
Atypical background somatic mutant frequencies at the HPRT locus in children and adults with Down syndrome.
Mutation research - 17 Jul 1998
Finette B A, Rood B, Poseno T, Vacek P, Pueschel S, Homans A C
Abstract excerpt
People with Down syndrome are 10-30 fold more likely to develop leukemia than the normal population. To date, little is known regarding the molecular mechanisms underlying this phenomenon. We have previously demonstrated that the spontaneous somatic mutant frequency (Mf) at a reporter gene, hypox...
Topics
- Adolescent
- Adult
- Age Factors
- Case-Control Studies
- Child
- Child, Preschool
- DNA Damage
- DNA Repair
- Down Syndrome
- Female
- Genes, Reporter
- Humans
- Hypoxanthine Phosphoribosyltransferase
- Infant
- Leukemia
- Male
- Middle Aged
- Mutation