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Article

Atypical background somatic mutant frequencies at the HPRT locus in children and adults with Down syndrome.

Mutation research - 17 Jul 1998

Finette B A, Rood B, Poseno T, Vacek P, Pueschel S, Homans A C

Abstract excerpt

People with Down syndrome are 10-30 fold more likely to develop leukemia than the normal population. To date, little is known regarding the molecular mechanisms underlying this phenomenon. We have previously demonstrated that the spontaneous somatic mutant frequency (Mf) at a reporter gene, hypoxanthine-guanine phosphoribosyl transferase (HPRT), from a normal population showed a strict age dependency with an...

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PMID: 9726004
DOI: 10.1016/s0027-5107(98)00024-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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