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Article

G protein hyperactivation of the Caenorhabditis elegans adenylyl cyclase SGS-1 induces neuronal degeneration.

The EMBO journal - 1 Sept 1998

Korswagen H C, van der Linden A M, Plasterk R H

Abstract excerpt

Expression of a constitutively activated version of the heterotrimeric G protein alpha-subunit Galphas results in the swelling and vacuolization of a specific subset of ventral nerve cord motoneurons of Caenorhabditis elegans. A second site modifier (sgs-1) that completely suppresses this neuronal degeneration has been isolated. sgs-1 was cloned and was shown to encode an adenylyl cyclase which is most similar to...

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Identifiers

PMID: 9724641
DOI: 10.1093/emboj/17.17.5059
PMCID: PMC1170833

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Source receipt: pubmed, retrieved 7 Sept 2026.

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