Article
G protein hyperactivation of the Caenorhabditis elegans adenylyl cyclase SGS-1 induces neuronal degeneration.
The EMBO journal - 1 Sept 1998
Korswagen H C, van der Linden A M, Plasterk R H
Abstract excerpt
Expression of a constitutively activated version of the heterotrimeric G protein alpha-subunit Galphas results in the swelling and vacuolization of a specific subset of ventral nerve cord motoneurons of Caenorhabditis elegans. A second site modifier (sgs-1) that completely suppresses this neurona...
Topics
- Adenylyl Cyclases
- Amino Acid Sequence
- Animals
- Caenorhabditis elegans
- Cell Death
- Cloning, Molecular
- GTP-Binding Protein alpha Subunits, Gs
- Molecular Sequence Data
- Motor Neurons
- Mutation
- Nerve Tissue Proteins
- Nervous System
- Sequence Analysis, DNA
- Suppression, Genetic
- Tissue Distribution