Article
Glucocorticoid-induced apoptosis and regulation of NF-kappaB activity in human leukemic T cells.
Endocrinology - 1 Sept 1998
Ramdas J, Harmon J M
Abstract excerpt
Glucocorticoid-induced apoptosis was investigated in glucocorticoid-sensitive 6TG1.1 and resistant ICR27TK.3 human leukemic T cells. Following glucocorticoid treatment of 6TG1.1 cells, chromatin fragmentation was observed after a delay of 24 h. Fragmentation was not observed in ICR27TK.3 cells containing mutant glucocorticoid receptors (L753F) that are activation-deficient but retain the ability to repress AP-1...
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