Association of the HLA-A2 allele with an earlier age of onset of Alzheimer's disease.

doi:10.1111/j.1600-0404.1998.tb01735.x

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Article

Association of the HLA-A2 allele with an earlier age of onset of Alzheimer's disease.

Acta neurologica Scandinavica - 1 Aug 1998

Combarros O, Escribano J, Sánchez-Velasco P, Leyva-Cobián F, Oterino A, Leno C, Berciano J

Abstract excerpt

INTRODUCTION: The HLA-A2 allele has recently been considered as a risk factor in AD by advancing the age at onset of the disease, especially in subjects who were homozygous for the apoE epsilon4 allele. MATERIAL AND METHODS: We examined the distribution of apoE genotypes and A2 allele as a functi...

Topics

Adult
Age of Onset
Aged
Alleles
Alzheimer Disease
Apolipoproteins E
Female
HLA-A2 Antigen
Humans
Male
Middle Aged
Polymorphism, Genetic
Retrospective Studies

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