Article
[Association between the A2 allele of the HLA system and age at onset of Alzheimer's disease].
Presse medicale (Paris, France : 1983) - 1 Feb 2003
Nourhashémi F, Gillette-Guyonnet S, Fort M, Andrieu S, Abbal M, Albarède J-L, Vellas B
Abstract excerpt
OBJECTIVE: Alzheimer is a multifactor disease occurring in a sensitive genetic territory. The e4 allele of the apolipoprotein E (APO E) is a recognised factor of risk. Some studies have suggested an association between the A2 allele of the HLA system and an earlier onset of the disease notably when it appears before the age of 64 or after the age of 75. The aim of our study was to explore this hypothesis in an...
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