DNA damage and mutation: contributors to the age-related alterations in T cell-mediated immune responses?

doi:10.1016/s0047-6374(98)00018-9

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Article

DNA damage and mutation: contributors to the age-related alterations in T cell-mediated immune responses?

Mechanisms of ageing and development - 15 May 1998

Barnett Y A, Barnett C R

Abstract excerpt

The genetic material of our cells is susceptible to damage by a wide variety of extrinsic and intrinsic entities. The amount of genetic damage accumulated in vivo will depend upon an individual's ability to defend against and/or repair DNA damage. T cells in vivo have been shown to accumulate DNA...

Topics

Aging
Animals
Antioxidants
DNA Damage
DNA Repair
Humans
Lymphocytes
Mutation
Nitrogen
Reactive Oxygen Species
T-Lymphocytes

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