Principles of control and selection in mammalian aging.

doi:10.1159/000213604

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Article

Principles of control and selection in mammalian aging.

Gerontology - 1 Jan 1994

Hartwig M

Abstract excerpt

Acquisition of immunologic self-tolerance by clonal deletion in the thymus is concluded to be a critical process in immune aging and is found to be transiently protected from genetic instability by means of a feedback surveillance which functions at the expense of chronic thymic involution. In th...

Topics

Aging
Alzheimer Disease
Animals
Autoimmunity
Biological Evolution
Humans
Mutation
Thymus Gland

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