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Article

Principles of control and selection in mammalian aging.

Gerontology - 1 Jan 1994

Hartwig M

Abstract excerpt

Acquisition of immunologic self-tolerance by clonal deletion in the thymus is concluded to be a critical process in immune aging and is found to be transiently protected from genetic instability by means of a feedback surveillance which functions at the expense of chronic thymic involution. In the immune control of mammalian aging, principles of Darwinian natural selection are suggested to work at the cellular...

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Identifiers

PMID: 7867960
DOI: 10.1159/000213604

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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