Article
An N-terminal region of LukF of staphylococcal leukocidin/gamma-hemolysin crucial for the biological activity of the toxin.
Bioscience, biotechnology, and biochemistry - 1 Jul 1998
Kaneko J, Mascarenas A L, Huda M N, Tomita T, Kamio Y
Abstract excerpt
The two staphylococcal bi-component toxins, leukocidin and gamma-hemolysin share LukF [Kamio et al, FEBS Lett., 321, 15-18 (1993)]. This report identifies the pivotal amino acid residues in the N-terminal region of LukF for the leukocytolytic and hemolytic activities in the presence of LukS and HIg2, respectively, measuring the toxin activity of a series of LukF mutants with truncated N-terminals. The data...
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