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Article

Isotypic Variants of the Interferon-Inducible Transcriptional Repressor IFI 16 Arise through Differential mRNA Splicing

1 Aug 1998

Abstract excerpt

We recently demonstrated that IFI 16, a human member of a family of interferon-inducible nuclear proteins, can function as a potent repressor of transcription. All members of this family are found in the nucleus and contain 1 or 2 copies of a conserved 200 amino acid repeat domain. IFI 16 migrates on SDS-PAGE as three distinct protein species (IFI 16A, 16B, 16C) clustered at 85-95 kDa, and we therefore set out to...

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PMID: 9718316
DOI: 10.1021/bi981069a

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