Article
A vigorous virus-specific CD4+ T cell response may contribute to the association of HLA-DR13 with viral clearance in hepatitis B.
Clinical and experimental immunology - 1 Aug 1998
Diepolder H M, Jung M C, Keller E, Schraut W, Gerlach J T, Grüner N, Zachoval R, Hoffmann R M, Schirren C A, Scholz S, Pape G R
Abstract excerpt
A strong virus-specific CD4+ and CD8+ T lymphocyte response to hepatitis B virus (HBV) has been associated with viral clearance, but little is known about factors determining the individual's ability to mount such a T cell response. Recently a strong association between the HLA class II allele DR...
Topics
- Acute Disease
- Alleles
- CD4-Positive T-Lymphocytes
- Clone Cells
- Epitopes
- HLA-DR Antigens
- HLA-DR Serological Subtypes
- Hepatitis B
- Hepatitis B Core Antigens
- Histocompatibility Testing
- Humans
- Jaundice
- Leukocytes, Mononuclear
- Lymphocyte Activation