Article
A vigorous virus-specific CD4+ T cell response may contribute to the association of HLA-DR13 with viral clearance in hepatitis B.
Clinical and experimental immunology - 1 Aug 1998
Diepolder H M, Jung M C, Keller E, Schraut W, Gerlach J T, Grüner N, Zachoval R, Hoffmann R M, Schirren C A, Scholz S, Pape G R
Abstract excerpt
A strong virus-specific CD4+ and CD8+ T lymphocyte response to hepatitis B virus (HBV) has been associated with viral clearance, but little is known about factors determining the individual's ability to mount such a T cell response. Recently a strong association between the HLA class II allele DR13 and a self-limited course of HBV infection has been described. In the present study of 33 patients with acute...
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