Article
[What functions do six different genes for secretory proteinases have in Candida albicans?].
Mycoses - 1 Jan 1998
Hube B, Sanglard D, Schaller M, Ibrahim A, Odds F C, Gow N A
Abstract excerpt
Secreted Aspartate Proteinases (Sap) are among those factors of the human pathogen Candida albicans, which promote infections in the immunocompromised host. Sap isoenzymes are encoded by at least nine different genes (SAP1-9), which are differentially regulated in vitro. RT-PCR analysis during experimental infections and from patient samples confirmed the expression of SAP genes in vivo. However, while Sap2 is...
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