Article
Allelotype mapping of unstable microsatellites establishes direct lineage continuity between endometrial precancers and cancer.
Cancer research - 1 Oct 1996
Mutter G L, Boynton K A, Faquin W C, Ruiz R E, Jovanovic A S
Abstract excerpt
Progressive microsatellite changes in replication error positive (RER+) endometrium were used to reconstruct evolutionary stages of nonfamilial adenocarcinoma. RER+ putative endometrial precancers (atypical endometrial hyperplasias) progress to RER+ carcinomas, which retain some of the altered microsatellites acquired in earlier precursor stages. The RER+ phenotype may provide a specific marker for early-stage...
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