Article
High resolution HLA class I typing by reference strand mediated conformation analysis (RSCA).
Tissue antigens - 1 Jul 1998
Argüello J R, Little A M, Bohan E, Goldman J M, Marsh S G, Madrigal J A
Abstract excerpt
We describe the application of RSCA for the high resolution typing of alleles encoded within the highly polymorphic HLA class I system. RSCA differs from other sequence based typing methodologies in that the HLA type is assigned on the basis of differences in DNA conformation between different HLA alleles. HLA class I locus specific PCR was performed on the sample to be HLA typed and the PCR product mixed with a...
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