Article
[Respective roles of the products of the mdr1 and p53 genes in drug resistance of bronchial cancers].
Bulletin du cancer - 1 Dec 1994
Peoc'h M, Brambilla E, Moro D, Gazzeri S, Brambilla C
Abstract excerpt
Expression of mdr1 and p53 was assessed on 119 cases of bronchial carcinomas, and compared with clinical chemoresistance. mdr1 expression was evaluated by immunohistochemistry (IHC), using the monoclonal antibody JSB1. The study of p53 expression was performed by both IHC, using six different antibodies, and Northern blotting. We observed a correlation between the expression of mdr1 and the presence of a mutation...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Adenocarcinoma
- Bronchial Neoplasms
- Carcinoma, Small Cell
- Cell Differentiation
- Drug Resistance, Multiple
- Gene Expression
- Genes, p53
- Humans
- Immunohistochemistry