Article
Shiga toxin binds human platelets via globotriaosylceramide (Pk antigen) and a novel platelet glycosphingolipid.
Infection and immunity - 1 Sept 1998
Cooling L L, Walker K E, Gille T, Koerner T A
Abstract excerpt
Hemolytic-uremic syndrome is a clinical syndrome characterized by acute renal failure, microangiopathic hemolytic anemia, and thrombocytopenia that often follows infection by Shiga toxin- or verotoxin-producing strains of Escherichia coli. Because thrombocytopenia and platelet activation are hall...
Topics
- Antigens, Nuclear
- Bacterial Toxins
- Blood Platelets
- Carbohydrate Sequence
- Glycolipids
- Glycoside Hydrolases
- Glycosphingolipids
- Humans
- Lactosylceramides
- Molecular Sequence Data
- Nuclear Proteins
- Phenotype
- Receptors, Cell Surface
- Shiga Toxins
- Shigella dysenteriae
- Trihexosylceramides