Article
A unique pattern of photoreceptor degeneration in cyclin D1 mutant mice.
Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 1998
Ma C, Papermaster D, Cepko C L
Abstract excerpt
Cyclin D1-deficient mice have small eyes with thin retinas. We observed that there was a lower level of retinal cell proliferation and a unique pattern of photoreceptor cell death. Death was first observed in scattered clusters of cells in the retina. It then appeared to spread from these few cel...
Topics
- Animals
- Apoptosis
- Cell Count
- Cyclin D1
- Genes, bcl-2
- Immunohistochemistry
- Interneurons
- Mice
- Mice, Inbred DBA
- Mice, Knockout
- Mice, Transgenic
- Microscopy, Electron
- Mitosis
- Models, Biological
- Mutation
- Nerve Degeneration
- Photoreceptor Cells
- Retina