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Article

A unique pattern of photoreceptor degeneration in cyclin D1 mutant mice.

Proceedings of the National Academy of Sciences of the United States of America - 18 Aug 1998

Ma C, Papermaster D, Cepko C L

Abstract excerpt

Cyclin D1-deficient mice have small eyes with thin retinas. We observed that there was a lower level of retinal cell proliferation and a unique pattern of photoreceptor cell death. Death was first observed in scattered clusters of cells in the retina. It then appeared to spread from these few cells to nearby photoreceptors, eventually producing extensive holes in the photoreceptor layer. These holes appeared to...

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Identifiers

PMID: 9707579
DOI: 10.1073/pnas.95.17.9938
PMCID: PMC21440

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