Article
A functional serotonin transporter (5-HTT) polymorphism is associated with psychosis in neuroleptic-free schizophrenics.
Molecular psychiatry - 1 Jul 1998
Malhotra A K, Goldman D, Mazzanti C, Clifton A, Breier A, Pickar D
Abstract excerpt
The neurotransmitter serotonin has been implicated in the pathophysiology of psychosis. The serotonin transporter (5-HTT) plays a critical role in regulation of serotonergic function. A recently identified polymorphism in the promoter region of the 5-HTT gene (5-HTTLPR) produces significant diffe...
Topics
- Adult
- Age of Onset
- Antipsychotic Agents
- Brief Psychiatric Rating Scale
- Carrier Proteins
- Female
- Genotype
- Hallucinations
- Humans
- Male
- Membrane Glycoproteins
- Membrane Transport Proteins
- Nerve Tissue Proteins
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Psychotic Disorders
- Schizophrenia
- Schizophrenic Psychology