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Article

Inorganic phosphate induces apoptosis of osteoblast-like cells in culture.

Bone - 1 Sept 2000

Meleti Z, Shapiro I M, Adams C S

Abstract excerpt

The major goal of this investigation was to test the hypothesis that one of the major products of bone resorption, inorganic phosphate (Pi), activates osteoblast apoptosis. Osteoblast-like cells were isolated from explants of human bone. In monolayer culture, these cells showed an osteogenic phenotype. Thus, the cells exhibited raised alkaline phosphatase activity, expressed osteogenic messenger RNA transcripts,...

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Identifiers

PMID: 10962346
DOI: 10.1016/s8756-3282(00)00346-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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