Article
Cytokeratin expression in breast cancer: phenotypic changes associated with disease progression.
Cytometry - 1 Aug 1998
Brotherick I, Robson C N, Browell D A, Shenfine J, White M D, Cunliffe W J, Shenton B K, Egan M, Webb L A, Lunt L G, Young J R, Higgs M J
Abstract excerpt
Transition from a normal to a cancerous state is marked by alterations in the cytoskeletal structure of those cells involved. We have examined such changes to determine if these transitions are markers of disease progression. Cytokeratin (CK) protein and messenger RNA (mRNA) expression were examined in malignant and benign breast tissues. Flow cytometric results demonstrated a significant correlation between...
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