Efficient trial designs for studying combination antiretroviral treatments in patients with various resistance profiles.

doi:10.1086/515647

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Article

Efficient trial designs for studying combination antiretroviral treatments in patients with various resistance profiles.

The Journal of infectious diseases - 1 Aug 1998

Gilbert P, DeGruttola V, Hammer S

Abstract excerpt

Selecting antiretroviral therapies for human immunodeficiency virus type 1-infected persons is complicated by the availability of a vast number of potentially useful drug combinations and by extensive variation among patients in their resistance to various drugs. AIDS clinical trials have used de...

Topics

Anti-HIV Agents
Clinical Trials as Topic
Drug Interactions
Drug Resistance, Microbial
Drug Resistance, Multiple
Drug Therapy, Combination
Genotype
HIV Infections
Humans
Models, Statistical
Research Design
Sample Size

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