Article
Antiretroviral resistance in clinical practice.
International journal of STD & AIDS - 1 Mar 2001
Geretti A M, Easterbrook P
Abstract excerpt
Despite the success of potent combination therapy against HIV, a large proportion of patients experiences treatment failure. Due to the high degree of plasticity of the HIV genome, ongoing virus replication in the presence of drug pressure will result in the selection of virus mutants with reduced drug susceptibility. As a result, antiretroviral drug-resistance is a common denominator in treatment failure. Two...
Topics
- Acquired Immunodeficiency Syndrome
- Anti-HIV Agents
- Antiretroviral Therapy, Highly Active
- Clinical Trials as Topic
- Drug Resistance, Microbial
- Drug Resistance, Multiple
- Education, Medical, Continuing
- Genotype
- HIV
- HIV Infections
- HIV Protease