Article
Analysis of a multi-mutant herpes simplex virus type 1 for gene transfer into sympathetic preganglionic neurons and a comparison to adenovirus vectors.
Neuroscience - 1 Oct 1998
Levatte M A, Cassam A K, Dekaban G A, Weaver L C
Abstract excerpt
A non-replicating triple-mutant herpes simplex virus (14H delta 3vhsZ) expressing the bacterial marker enzyme beta-galactosidase, was assessed for neurotropism and cytopathic effects as a vector for gene transfer into differentiated phaeochromocytoma 12 cells in vitro and into spinal sympathetic...
Topics
- Adenoviridae
- Animals
- Autonomic Fibers, Preganglionic
- Chlorocebus aethiops
- Choline O-Acetyltransferase
- Cricetinae
- Gene Transfer Techniques
- Genetic Vectors
- Herpesvirus 1, Human
- Humans
- Immunohistochemistry
- Male
- Mesocricetus
- Mutation
- NADPH Dehydrogenase
- PC12 Cells
- Rats
- Sympathetic Nervous System