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Article

Pathogenicity of Live, Attenuated SIV After Mucosal Infection of Neonatal Macaques

24 Mar 1995

Abstract excerpt

Adult macaques do not develop disease after infection with a nef deletion mutant of the simian immunodeficiency virus (SIV) and are protected against challenge with pathogenic virus. This finding led to the proposal to use nef-deleted viruses as live, attenuated vaccines to prevent human acquired immunodeficiency syndrome (AIDS). In contrast, neonatal macaques developed persistently high levels of viremia after...

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PMID: 7892606
DOI: 10.1126/science.7892606

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