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Article

Identification of the neurofibromatosis type 1 gene product.

1 Nov 1991

Abstract excerpt

The gene for neurofibromatosis type 1 (NF1) was recently identified by positional cloning. The complete cDNA encodes a polypeptide of 2818 amino acids. To study the NF1 gene product, antibodies were raised against both fusion proteins and synthetic peptides. Initial characterization of two anti-peptide antibodies and one fusion-protein antibody demonstrated a specific protein of approximately 250 kDa by both...

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PMID: 1946382
DOI: 10.1073/pnas.88.21.9658

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