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Article

An unknown genetic defect increases venous thrombosis risk, through interaction with protein C deficiency.

American journal of human genetics - 1 Aug 1998

Hasstedt S J, Bovill E G, Callas P W, Long G L

Abstract excerpt

We used two-locus segregation analysis to test whether an unknown genetic defect interacts with protein C deficiency to increase susceptibility to venous thromboembolic disease in a single large pedigree. Sixty-seven pedigree members carry a His107Pro mutation in the protein C gene, which reduces protein C levels to a mean of 46% of normal. Twenty-one carriers of the mutation and five other pedigree members had...

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Identifiers

PMID: 9683579
DOI: 10.1086/301947
PMCID: PMC1377289

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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