Article
Cellular interactions during the development of autoimmunity in a fetal lamb model of self-antigen deprivation.
Clinical immunology and immunopathology - 1 Jul 1998
King K J, Hagan R P, Mieno M, McCullagh P
Abstract excerpt
Anti-thyroid autoimmune responses have been examined in fetal lambs, the immune systems of which had matured in the absence of exposure to thyroid-specific antigens. The lymphocytic infiltrate in self-thyroid tissue reintroduced into autoimmune lambs showed well-differentiated B and T cell domain...
Topics
- Animals
- Antigen Presentation
- Autoantibodies
- Autoantigens
- Autoimmunity
- B-Lymphocytes
- Disease Models, Animal
- Female
- Fetus
- In Vitro Techniques
- Iodide Peroxidase
- Lymph Nodes
- Lymphocyte Activation
- Phenotype
- Pregnancy
- Sheep
- T-Lymphocytes
- Thyroglobulin