Article
Protection of chickens against experimental fowl typhoid using a nuoG mutant of Salmonella serotype Gallinarum.
Vaccine - 1 Jan 2000
Zhang-Barber L, Turner A K, Dougan G, Barrow P A
Abstract excerpt
A nuoG mutation in NADH dehydrogenase I was introduced into a virulent strain of Salmonella serotype Gallinarum, the causative agent of fowl typhoid, using gene replacement with a nuoG open reading frame inactivated by insertion of DNA encoding a kanamycin resistance determinant. The S. Gallinarum nuoG mutant, named SG9NGK, was highly attenuated in chickens. SG9NGK colonized the caeca of chickens less efficiently...
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