Physiology, pathogenicity and immunogenicity of lon and/or cpxR deleted mutants of Salmonella Gallinarum as vaccine candidates for fowl typhoid.

doi:10.1051/vetres/2010031

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Article

Physiology, pathogenicity and immunogenicity of lon and/or cpxR deleted mutants of Salmonella Gallinarum as vaccine candidates for fowl typhoid.

Veterinary research - 1 Jan 2000

Matsuda Kiku, Chaudhari Atul A, Kim Sam Woong, Lee Kyeong Min, Lee John Hwa

Abstract excerpt

To construct a novel live vaccine candidate for fowl typhoid (FT) caused by Salmonella Gallinarum (SG), the lon and cpxR genes that are related to host-pathogen interaction were deleted from a wild type SG using the allelic exchange method. The mutants were grown normally, as was the wild type. The biochemical properties of the mutants remained very similar to those of the wild-type, while JOL914 (Deltalon) and...

Topics

Animals
Bacterial Proteins
Chickens
Gene Expression Regulation, Bacterial
Mutation
Salmonella
Salmonella Infections, Animal
Salmonella Vaccines
Vaccines, Attenuated

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Identifiers

PMID: 20487719
DOI: 10.1051/vetres/2010031
PMCID: PMC2887653

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