Lithium long-term treatment in mood disorders: clinical and genetic predictors.

doi:10.1517/14622416.3.1.117

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Article

Lithium long-term treatment in mood disorders: clinical and genetic predictors.

Pharmacogenomics - 1 Jan 2002

Serretti Alessandro

Abstract excerpt

Lithium is the most widely used long-term treatment for recurrent mood disorders. Despite its proven efficacy, patients show a variable response, ranging from complete efficacy to no influence at all. This paper reviews possible predictors of response focusing on molecular genetic studies. The functional polymorphism in the upstream regulatory region of the serotonin transporter gene (5-HTTLPR) has been...

Topics

Carrier Proteins
Genetic Variation
Humans
Lithium
Membrane Glycoproteins
Membrane Transport Proteins
Mood Disorders
Nerve Tissue Proteins
Pharmacogenetics
Polymorphism, Genetic
Second Messenger Systems
Serotonin Plasma Membrane Transport Proteins
Time Factors

Source

Open in PubMed

Identifiers

PMID: 11966408
DOI: 10.1517/14622416.3.1.117

Genes

INPP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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