Article
Analysis of a core domain in Drosophila DNA topoisomerase II. Targeting of an antitumor agent ICRF-159.
The Journal of biological chemistry - 31 Jul 1998
Chang S, Hu T, Hsieh T S
Abstract excerpt
To investigate the biochemical properties of individual domains of eukaryotic topoisomerase (topo) II, two truncation mutants of Drosophila topo II were generated, ND406 and core domain. Both mutants lack the ATPase domain, corresponding to the N-terminal 406 amino acid residues in Drosophila pro...
Topics
- Adenosine Triphosphatases
- Animals
- Antineoplastic Agents
- Centrifugation, Density Gradient
- DNA Topoisomerases, Type II
- DNA, Circular
- Drosophila
- Mutation
- Nucleic Acid Conformation
- Protein Conformation
- Razoxane
- Substrate Specificity