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Article

Structure/function relationship studies on the T/S residues 173-177 of rat ODC.

Biochimica et biophysica acta - 28 Jul 1998

Matés J M, del Valle A E, Urdiales J L, Coleman C S, Feith D, Olmo M T, Pegg A E, Sánchez-Jiménez F

Abstract excerpt

A well-conserved T/S cluster was detected among vertebrate ornithine decarboxylase by computer analysis (E. Viguera, O. Trelles, J.L. Urdiales, J.M. Matés, F. Sánchez-Jiménez, Trends Biochem. Sci. 19 (1994) 318-319). In the present report we studied the role of these residues (173, 176 and 177 in rat ornithine decarboxylase (ODC)) in enzymic activity and stability by in vitro expression, kinetic characterization...

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PMID: 9675257
DOI: 10.1016/s0167-4838(98)00090-9

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