Article
Identification of viral mutants by mass spectrometry.
Proceedings of the National Academy of Sciences of the United States of America - 21 Jul 1998
Lewis J K, Bendahmane M, Smith T J, Beachy R N, Siuzdak G
Abstract excerpt
A method to identify mutations of virus proteins by using protein mass mapping is described. Comparative mass mapping was applied to a structural protein of the human rhinovirus Cys1199 --> Tyr mutant and to genetically engineered mutants of tobacco mosaic virus. The information generated from this approach can rapidly identify the peptide or protein containing the mutation and, in cases when nucleic acid...
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