Styrylquinoline derivatives: a new class of potent HIV-1 integrase inhibitors that block HIV-1 replication in CEM cells.

doi:10.1021/jm980043e

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Article

Styrylquinoline derivatives: a new class of potent HIV-1 integrase inhibitors that block HIV-1 replication in CEM cells.

Journal of medicinal chemistry - 16 Jul 1998

Mekouar K, Mouscadet J F, Desmaële D, Subra F, Leh H, Savouré D, Auclair C, d'Angelo J

Abstract excerpt

On the basis of the fact that several polynucleotidyl transferases, related to HIV integrase, contain in their active site two divalent metal cations, separated by ca. 4 A, new potential HIV integrase inhibitors were designed, in which a quinoline substructure is linked to an aryl nucleus possess...

Topics

Anti-HIV Agents
Cell Line, Transformed
HIV Integrase
HIV Integrase Inhibitors
HIV-1
Humans
Mutation
Quinolines
Sequence Deletion
Styrenes
Tumor Cells, Cultured
Virus Replication

Source

Open in PubMed

Identifiers

PMID: 9667973
DOI: 10.1021/jm980043e

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9667973-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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