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Article

The design of 8-hydroxyquinoline tetracyclic lactams as HIV-1 integrase strand transfer inhibitors.

European journal of medicinal chemistry - 19 Jul 2016

Velthuisen Emile J, Johns Brian A, Temelkoff David P, Brown Kevin W, Danehower Susan C

Abstract excerpt

A novel series of HIV-1 integrase strand transfer inhibitors were designed using the venerable two-metal binding pharmacophore model and incorporating structural elements from two different literature scaffolds. This manuscript describes a number of 8-hydroxyquinoline tetracyclic lactams with exceptional antiviral activity against HIV-1 and little loss of potency against the IN signature resistance mutations...

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Source

Identifiers

PMID: 27092410
DOI: 10.1016/j.ejmech.2016.03.038

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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