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Article

Inhibition of the human immunodeficiency virus type 1 integrase by guanosine quartet structures.

Biochemistry - 29 Oct 1996

Mazumder A, Neamati N, Ojwang J O, Sunder S, Rando R F, Pommier Y

Abstract excerpt

An oligonucleotide (T30177) composed entirely of deoxyguanosine and thymidine has previously been shown to fold upon itself in the presence of potassium into a highly stable four-stranded DNA structure containing two stacked deoxyguanosine quartets (G4s). T30177 also protects host cells from the cytopathic effects of human immunodeficiency virus type 1 (HIV-1). We report that this G4 oligonucleotide is the most...

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PMID: 8901518
DOI: 10.1021/bi960541u

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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