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Article

Boundary formation in Drosophila wing: Notch activity attenuated by the POU protein Nubbin.

Science (New York, N.Y.) - 17 Jul 1998

Neumann C J, Cohen S M

Abstract excerpt

Cell interactions mediated by Notch-family receptors have been implicated in the specification of tissue boundaries in vertebrate and insect development. Although Notch ligands are often widely expressed, tightly localized activation of Notch is critical for the formation of sharp boundaries. Evidence is presented here that the POU domain protein Nubbin contributes to the formation of a sharp dorsoventral...

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Identifiers

PMID: 9665883
DOI: 10.1126/science.281.5375.409

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Boundary formation in Drosophila wing: Notch activity attenuated by the POU protein Nubbin.PMID 9665883Read ↗

Nubbin encodes a POU-domain protein required for proximal-distal patterning in the Drosophila wing.Semantic proximity Read ↗

fringe, a Boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development.Semantic proximity Read ↗

A gain-of-function suppressor screen for genes involved in dorsal-ventral boundary formation in the Drosophila wing.Semantic proximity Read ↗

Fringe-dependent separation of dorsal and ventral cells in the Drosophila wing.Semantic proximity Read ↗

A permissive role of Notch in maintaining the DV affinity boundary of the Drosophila wing.Semantic proximity Read ↗

Long range repression conferring boundaries of Ultrabithorax expression in the Drosophila embryo.Semantic proximity Read ↗

In situ mutational screening and CRISPR interference define apterous cis-regulatory inputs during compartment boundary formation.Semantic proximity Read ↗

Regulation and function of the terminal gap gene huckebein in the Drosophila blastoderm.Semantic proximity Read ↗

Signalling crosstalk at the leading edge controls tissue closure dynamics in the Drosophila embryo.Semantic proximity Read ↗

Downregulation of Jun kinase signaling in the amnioserosa is essential for dorsal closure of the Drosophila embryo.Semantic proximity Read ↗

The tumour suppressor gene l(2)giant discs is required to restrict the activity of Notch to the dorsoventral boundary during Drosophila wing development.Semantic proximity Read ↗

Scalloped and strawberry notch are target genes of Notch signaling in the context of wing margin formation in Drosophila.Semantic proximity Read ↗

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