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Article

Differential modulation of CYP2E1 activity by cAMP-dependent protein kinase upon Ser129 replacement.

Experimental cell research - 10 Jul 1998

Oesch-Bartlomowicz B, Padma P R, Becker R, Richter B, Hengstler J G, Freeman J E, Wolf C R, Oesch F

Abstract excerpt

Many toxic compounds are activated by cytochrome P450 (CYP) 2E1 to reactive metabolites, which represents a potential hazard for cellular homeostasis. Therefore knowledge about CYP2E1 regulation could be of great biological importance. It has been shown that CYP2E1 is controlled transcriptionally and post-translationally by phosphorylation. In the present study we investigated the role of serine-129 (Ser129) in...

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PMID: 9665827
DOI: 10.1006/excr.1998.4120

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PNP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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