Differential modulation of CYP2E1 activity by cAMP-dependent protein kinase upon Ser129 replacement.

doi:10.1006/excr.1998.4120

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Article

Differential modulation of CYP2E1 activity by cAMP-dependent protein kinase upon Ser129 replacement.

Experimental cell research - 10 Jul 1998

Oesch-Bartlomowicz B, Padma P R, Becker R, Richter B, Hengstler J G, Freeman J E, Wolf C R, Oesch F

Abstract excerpt

Many toxic compounds are activated by cytochrome P450 (CYP) 2E1 to reactive metabolites, which represents a potential hazard for cellular homeostasis. Therefore knowledge about CYP2E1 regulation could be of great biological importance. It has been shown that CYP2E1 is controlled transcriptionally...

Topics

Amino Acid Substitution
Animals
Bucladesine
Cells, Cultured
Cricetinae
Cricetulus
Cyclic AMP-Dependent Protein Kinases
Cytochrome P-450 CYP2E1
Dimethylnitrosamine
Enzyme Induction
Fibroblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Inactivation, Metabolic

Isoniazid

Lung

Male

Mice

Mice, Inbred BALB C

Microsomes, Liver

Source

Open in PubMed

Identifiers

PMID: 9665827
DOI: 10.1006/excr.1998.4120

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9665827-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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