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Article

Enhanced dephosphorylation of cAMP-dependent protein kinase by oxidation and thiol modification.

The Journal of biological chemistry - 28 Jan 2005

Humphries Kenneth M, Deal Michael S, Taylor Susan S

Abstract excerpt

The catalytic subunit of cAMP-dependent protein kinase (PKA) is phosphorylated at threonine 197 and serine 338. Phosphorylation of threonine 197, located in the activation loop, is required for coordinating the active site conformation and optimal enzymatic activity. However, this phosphorylation has not been widely appreciated as a regulatory site because of the apparent constitutive nature of the...

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Identifiers

PMID: 15533936
DOI: 10.1074/jbc.M410242200

Genes

PDK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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