Article
Mutational analysis of the tumor suppressor Smad2 in acute lymphoid and myeloid leukemia.
Leukemia - 1 Jul 1998
Wieser R, Gruber B, Rieder H, Fonatsch C
Abstract excerpt
Smad4 is a tumor suppressor that is inactivated in about 50% of pancreatic carcinomas. Mutations in this gene have also been found with variable, yet much lower frequency in other tumor types and were absent from a large number of samples from patients with hematological malignancies. Smad2 shows...
Topics
- Base Sequence
- Bone Marrow Cells
- Chromosomes, Human, Pair 18
- Conserved Sequence
- DNA Mutational Analysis
- DNA, Neoplasm
- DNA-Binding Proteins
- Gene Deletion
- Genes, Tumor Suppressor
- Humans
- Leukemia, Erythroblastic, Acute
- Leukemia, Megakaryoblastic, Acute
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- RNA, Neoplasm
- Smad2 Protein